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KMID : 0383019710020010029
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Alumni Bulletin of Internal Medicine
1971 Volume.2 No. 1 p.29 ~ p.40
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The Renal Anemia
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Abstract
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To clarify the characters of renal anemia, 146 cases of chronic renal failure patients at the Seoul National Univ. Hospital were analyzed. Various renal function as hematologic findings and clinical pictures were observed. Among these patients, ferrokinetics in 14 cases and red cell survivals, (5Cr T+) in 22 cases were measured by using radioactive iron (39Fe) and chromium (Cr).
Results obtained were as follows.
1. There were no definite correlation’s among hemoglobin values and blood urea nitrogen’s and serum creatinine levels as well as creatinine clearance. However, hemoglobin values ranged above 6.0 to 9.0 gm/dl in most cases. When the degree of renal impairment was prominent, hemoglobin values tended to be lower.
2. Most of the cases (about 90%) showed normocytic, normochromic anemia.
3. The values of serum iron were-within-normal range.
4. Red cell survival time (51Cr T4) measured with 51Cr labeled modified wash method in 22 cases was reduced in inverse proportion to BUN levels.
5. Plasma iron (59Fe) turnover rate was normal. Red cell iron utilization rate, red cell iron turnover rate and circulating red cell iron value were reduced respectively. Red cell iron concent-ration was not changed.
Above results suggest that renal anemia is caused by interaction of a number of factors. The main mechanism concerned seems to be a deficit in stimulation and proliferation of erythroid marrow (malproliferative anemia proliferative disorder) in addition to homolysis and blood loss.
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